Genome: The Autobiography of a Species in 23 Chapters (P.S.) (Paperback)
by Matt Ridley (Author) "In the beginning was the word..." (more)
Key Phrases: antagonistic genes, asthma gene, imprinted genes, United States, Francis Crick, Mother Nature (more...)

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Editorial Reviews
Amazon.com
Science writer Matt Ridley has found a way to tell someone else's story without being accused of plagiarism. Genome: The Autobiography of a Species in 23 Chapters delves deep within your body (and, to be fair, Ridley's too) looking for dirt dug up by the Human Genome Project. Each chapter pries one gene out of its chromosome and focuses on its role in our development and adult life, but also goes further, exploring the implications of genetic research and our quickly changing social attitudes toward this information. Genome shies away from the "tedious biochemical middle managers" that only a nerd could love and instead goes for the A-material: genes associated with cancer, intelligence, sex (of course), and more.

Readers unfamiliar with the jargon of genetic research needn't fear; Ridley provides a quick, clear guide to the few words and concepts he must use to translate hard science into English. His writing is informal, relaxed, and playful, guiding the reader so effortlessly through our 23 chromosomes that by the end we wish we had more. He believes that the Human Genome Project will be as world-changing as the splitting of the atom; if so, he is helping us prepare for exciting times--the hope of a cure for cancer contrasts starkly with the horrors of newly empowered eugenicists. Anyone interested in the future of the body should get a head start with the clever, engrossing Genome. --Rob Lightner --This text refers to an out of print or unavailable edition of this title.

From Publishers Weekly
HSoon we'll know what's in our genes: next year, the Human Genome Project will have its first-draft map of our 23 chromosomes. Ridley (The Red Queen; The Origins of Virtue) anticipates the genomic news with an inventively constructed, riveting exposition of what we already know about the links between DNA and human life. His inviting prose proposes "to tell the story of the human genome... chromosome by chromosome, by picking a gene from each." That story begins with the basis of life on earth, the DNA-to-RNA-to-protein process (chapter one, "Life," and also chromosome one); the evolution of Homo sapiens (chromosome two, which emerged in early hominids when two ape chromosomes fused); and the discovery of genetic inheritance (which came about in part thanks to the odd ailment called alkaptonuria, carried on chromosome three). Some facts about your life depend entirely on a single gene--for example, whether you'll get the dreadful degenerative disease Huntington's chorea, and if so, at what age (chromosome four, hence chapter four: "Fate"). But most facts about you are products of pleiotropy, "multiple effects of multiple genes," plus the harder-to-study influences of culture and environment. (One asthma-related gene--but only one--hangs out on chromosome five.) The brilliant "whistle-stop tour of some... sites in the genome" passes through "Intelligence," language acquisition, embryology, aging, sex and memory before arriving at two among many bugbears surrounding human genetic mapping: the uses and abuses of genetic screening, and the ongoing debate on "genetic determinism" and free will. Ridley can explain with equal verve difficult moral issues, philosophical quandaries and technical biochemistry; he distinguishes facts from opinions well, and he's not shy about offering either. Among many recent books on genes, behavior and evolution, Ridley's is one of the most informative. It's also the most fun to read. Agent, Felicity Bryan.
Copyright 2000 Reed Business Information, Inc. --This text refers to an out of print or unavailable edition of this title.

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Product Details

* Paperback: 368 pages
* Publisher: Harper Perennial (May 30, 2006)
* Language: English
* ISBN-10: 0060894083
* ISBN-13: 978-0060894085
* Product Dimensions: 7.9 x 5.1 x 0.9 inches
* Shipping Weight: 8 ounces (View shipping rates and policies)
* Average Customer Review:

179 Reviews
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Key Phrases - SIPs: antagonistic genes, asthma gene, imprinted genes, hox genes, mushroom bodies (more)
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antagonistic genes, asthma gene, imprinted genes, hox genes, mushroom bodies, sexual antagonism, homeotic genes, paternal genes
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United States, Francis Crick, Mother Nature, Charles Darwin, James Watson, Rich Harris, Human Genome Project, Nancy Wexler, Richard Dawkins, Stone Age, Dean Hamer, Gregor Mendel, New Guinea, Steven Pinker, Archibald Garrod, Eugenics Society, Francis Galton, Karl Pearson, Lake Maracaibo, Robert Plomin, Robert Trivers, Second World War, The Brock, William Bateson
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Citations (learn more)
This book cites 19 books:

* The Red Queen: Sex and the Evolution of Human Nature by Matt Ridley in Front Matter, and Back Matter
* Essay on Man and Other Poems (Dover Thrift Editions) by Alexander Pope on page 1, and page 195
* A Shropshire Lad (Penguin Classics: Poetry First Editions) by A.E. Housman on page 120
* King Lear (The New Folger Library Shakespeare) by William Shakespeare on page 147
* Sigmund Freud (Get a Life) by Stephen Wilson on page 305

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Customer Reviews
179 Reviews
5 star: 62% (111)
4 star: 21% (39)
3 star: 8% (16)
2 star: 3% (7)
1 star: 3% (6)







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151 of 158 people found the following review helpful:
4.0 out of 5 stars Uneven, February 28, 2000
By Durand Sinclair (Sydney, Australia) - See all my reviews
This review is from: Genome: The Autobiography of a Species In 23 Chapters (Hardcover)
I'm not sure whether to give this book four or five stars...

FIVE STARS - because of how interesting the subject matter is. DNA, it seems, isn't a brilliant piece of software to make bodies. It's more a committee of chemicals each trying to propogate themselves, and often at odds with the other chemicals in DNA (97% of which don't actually do anything!) And this is the stuff that to a large extent makes us US!

FIVE STARS - because of how well written some sections are. Chapter 4, for instance, which talks about the researcher who not only can tell you IF you're going to get Huntington's chorea, but can tell you what age you'll get it, simply by counting the number of times a particular gene sequence repeats. I was left haunted by the question, if I had a high risk for H.C., would I get the test done, simply to know when the symptoms would start?

FIVE STARS - Because of the research. This is the most up to date book on the subject available at the moment. He cites research done as close as 1998.

BUT FOUR STARS - because although some parts were absolutely mind-blowingly interesting and could be considered _classic_ bits of writing, the prose in other parts seemed to get a bit heavy and tedious, and I had to put it down. I was surprised by my own reaction, having been so thoroughly entertained a few short chapters before. But it means I can't give it five stars, because that rating is for out and out classics. (Which this book nearly is. Damn.)
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54 of 57 people found the following review helpful:
5.0 out of 5 stars Tremendously entertaining, enjoyable romp through genetics, June 6, 2003
By Marc Cenedella "www.cenedella.com/stone" (East Village, New York, NY United States) - See all my reviews
(REAL NAME)
This review is from: Genome (Paperback)
This is the book that I wish Steven Pinker's "How the Mind Works" was. Matt Ridley unfolds the human genome for us in a crisply written and precise "Autobiography of a Species in 23 Chapters." OK, I don't know what the Hades that means, but this guy is a good writer, a smart scientist, and a friendly teacher of what is a really cool, but intimidating, branch of learning.

Ridley's got a little shtick, which he openly mocks himself, where his 23 chapters each represent one of the 23 human chromosomes. It's kind of an interesting little angle, you want to like this guy, anyway, so the shtick mostly works, although I don't really have a sense that each of our 23 chromosomes is a particular type of chromosome at the end of it.

Genome is a lot of good science explained with a clear, well-constructed hand. In an excellent seven-page introduction, Ridley answered for me all sorts of questions that my scientifically-literate yet communication-challenged science friends have been unable to answer, to wit:

"Imagine that the genome is a book.

There are twenty-three chapters, called Chromosomes.
Each chapter contains several thousand stories, called Genes.
Each story is made up of paragraphs, called Exons, which are interrupted by advertisements called Introns.
Each paragraph is made up of words, called Codons.
Each word is written in letters called Bases."

Very nicely done, brings it to an understandable level for the literate layperson, and establishes a very solid foundation from which he is able to unfold the rest of this story.

He handles the basic science very well, and mostly shys away from the "Believe It or Not!" school of science reporting, though the occasional oddity does pop up. One thing I found fascinating is the existence of "chimeras." Which is one creature ( a human, a mouse, anything) that has two different genomes in it: "Think of them as the opposite of identical twins: two different genomes in one body, instead of two different bodies with the same genome." This means that you could be the single body of two different people that had accidentally fused in the womb. Really weird thought experiment, no?

He places humans and our development in the context of our nearest genetic cousins - the chimpanzees and the gorillas and so forth. And elucidates a number of compare and contrast thoughts: "What it means is that the mating system of the species was changing. The promiscuity of the chimp, with its short sexual liaisons, and the harem polygamy of the gorilla, were being replaced with something much more monogamous: a declining ratio of sexual dimorphism is unambiguous evidence for that."

Ridley's wordcraft is superior. Enjoy all the learning, implications, and human foibles he packs into this one sentence on language acquisition:

"Thus, although no other primate can learn grammatical language at all - and we are indebted to many diligent, sometimes gullible and certainly wishful trainers of chimpanzees and gorillas for thoroughly exhausting all possibilities to the contrary - language is intimately connected with sound production and processing."

It is really just masterful. Even more enjoyable if you read it in an English accent on account of Ridley's living there according to the dust jacket.

In sum, if you are looking for an introduction to genetics, DNA, and our genome, and are the omnivore type of reader with a decent head on your shoulders, this book is for you. I enjoyed it tremendously and it's given me a very good grounding for my further reading into evolutionary psychology.

Enjoy strongly!
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88 of 108 people found the following review helpful:
2.0 out of 5 stars What a mess !, April 5, 2000
By Marianne Frye (Nashua, N.H., USA) - See all my reviews
(REAL NAME)
This review is from: Genome: The Autobiography of a Species In 23 Chapters (Hardcover)
I purchased this book for 2 reasons: 1.) I am a lay person interested in the human genome, 2.) Matt Ridley wrote an incomparable book called Red Queen, his treatment of sex and evolution. I was hoping for a similar treatment on the topic of the genome. What a disappointment!

The first problem was the identification of the chapters with the 23 chromosomes. That limited him to about one gene per chromosome with which to illustrate the topic of the chapter. Unfortunately not all the genes for learning, development and so on, are on the same chromosome. So in a book about science the actual science was almost totally absent. He then used old and current history/gossip to fill in the rest of the chapter. All the chapters were like this so there was no real common unifying argument running through the book. There was no focus ! In one chapter he digresses for around 10 pages on the eugenics movement. While that certainly is a valid topic for a science book of some sort, it does not have anything to do with the actual discoveries of the human genome.

The old history and current efforts were heavily laden with what I can only call insular British snobbery of the worst sort. In the Red Queen he actually presented opposing views and then presented a collegial set of arguments to show why he disagreed. In this work he seems to have done away with the presentation of ideas, and simply reduces other ideas he disagrees with to a few lines he then sneers at. Science reporting by scorn. He sneers at global warming, but doesn't say why, he sneers at the language studies conducted with monkeys -- and then turns around in a chapter and extols animal learning. The only sneer he does expand on, is his contempt for the British government's efforts to ban British beef due to mad cow disease (yes this too is part of a book on the human genome).

He seemed at particular pains to savage Americans, and to paint himself as a Briton living in England. He described one millionaire in the bio game as a 'high school drop out, former professional surfer, and Vietnam veteran' ? Now if his point is this person lacks an academic background then he is correct, but that is not stated -- the implication is that this person is worthless simply due to his unorthodox background. The tone of the whole book leads me to believe this book is in fact aimed at Ridley's British colleagues. He hopes to prove to them that though he has journeyed in the land of the barbarian (USA) he in fact has not been corrupted. That is the only way I can make sense of the tone of the book and the totally bizarre inclusion of Alexander the Great as a way to describe the ancient Egyptian god Ammon.

His forays into other areas could be a wonderful addition and support to a heavily science laden tome -- but these forays are almost all there is. He then wanders off topic to preach on items that he supports or that he is against. When he does not stray from the topic he tends to talk down and lecture his audience. He is against the use of presenting diseases as the means to explain a gene -- but then he repeatedly does this himself. He seems to miss the point that disease often helps to point out what went wrong and how. He forgets that his audience is unlikely to be sensation seekers, so he feels the need to periodically admonish us in what looks like 22 point type that genes aren't there to cause disease.

Finally this odd, confused book simply ends. He reaches the end of his 23rd chapter and simply stops. No summary, no wrap-up, no hopes or ideas for the future. The impression given is that someone just turned off the power, or that he completed the required number of words and that was all the time he wished to spend on the book.
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5.0 out of 5 stars serendipitous genes
I am not a geneticist and therefore have a very tiny knowledge of our genes. I am however, intensely interested in them, and in learning about them, so I bought this book as a... Read more
Published 10 days ago by Catherine Shafer

5.0 out of 5 stars Excellent Book
I read this book with only a moderate amount of background in Genetics. My interest is more like a hobbie so when I first started to read Matt Ridley's Genome I was afraid there... Read more
Published 6 months ago by J. Rodriguez

3.0 out of 5 stars Good science read, flawed by unnecessary political opining
Having read a number of books on this topic, I picked up this one while on vacation. I did enjoy the book overall and would recommend it to anyone interested in the subject. Read more
Published 7 months ago by Tim Freeman

4.0 out of 5 stars Genome-The Autobiography of a species in 23 chapters
Here is a book packed with newly-learned technical facts, yet it is easily read.

This book provided me with exactly the information, which I needed, at a key time in... Read more
Published 7 months ago by Ralph D. Hermansen

5.0 out of 5 stars Genetic Drift?
4.9 stars. I like this book very much. This is a "novel" approach to explaining the genome which will become even more important in the future. Read more
Published 8 months ago by ron lon

5.0 out of 5 stars Excellent Book
This is an excellent book. Matt Ridley mixes his complex opinions on Human civilisation with this great scientfic discovery. Excellent approach and good information.
Published 9 months ago by Prateek Sonthalia

5.0 out of 5 stars Understanding what makes us, US
This is a great primer for anyone wanting to understand what genes are - and they are not there to cause diseases!!!. Read more
Published 12 months ago by enna sevarg

4.0 out of 5 stars Compelling
I love this book. I only gave it 4 stars because I haven't finished it yet. It's one of those books that you can read over and over and learn new material each time. Read more
Published 13 months ago by Emily Smith

3.0 out of 5 stars review of genome
I only read one chapter but i thought it was well written and easy to read despite the complex subject matter.
Published 14 months ago by Rosemary Chester

5.0 out of 5 stars Genome
This is one of the most interesting books I have read in a long time. I am in the field of music and business. Read more
Published 17 months ago by Lisa

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